3D-Hub-O was created on an independent initiative, publications reflect only the views of the project owner.
3D-Hub Organoids
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    • A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids
    • A microfluidic platform integrating functional vascularized organoids-on-chip
    • A nomenclature consensus for nervous system organoids and assembloids
    • A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly
    • ABOUT 3D-Hub-O
    • Actuation enhances patterning in human neural tube organoids
    • Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids
    • Androgens increase excitatory neurogenic potential in human brain organoids
    • Antibody-dependent cellular cytotoxicity-inducing antibodies enhance the natural killer cell anti-cancer response against patient-derived pancreatic cancer organoids
    • Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response
    • Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids
    • Bladder cancer organoids as a functional system to model different disease stages and therapy response
    • Case report: Artificial thymic organoids facilitate clinical decisions for a patient with a TP63 variant and severe persistent T cell lymphopenia
    • CENTRES OF EXPERTISE
    • CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids
    • Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids
    • Chicken intestinal organoids: a novel method to measure the mode of action of feed additives
    • Clinical trials registers
    • Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons
    • Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
    • Contact
    • Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids
    • Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
    • Differentiation of Pluripotent Stem Cells Into Thymic Epithelial Cells and Generation of Thymic Organoids: Applications for Therapeutic Strategies Against APECED
    • DISEASE MECHANISMS
    • DISSEMINATION
    • DRUG DISCOVERY
    • Effects of Stem Cell Secretome on Opioid Receptors and Neuroplasticity in Cerebral Organoids
    • Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
    • ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
    • Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids
    • Expertise
    • Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
    • Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems
    • Functional neuronal circuitry and oscillatory dynamics in human brain organoids
    • Generation of 3D lacrimal gland organoids from human pluripotent stem cells
    • Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
    • Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
    • HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
    • High-resolution positron emission microscopy of patient-derived tumor organoids
    • Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
    • Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
    • Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
    • Human fetal brain self-organizes into long-term expanding organoids
    • Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid
    • Human organoids with an autologous tissue-resident immune compartment
    • Human organoids: New strategies and methods for analyzing human development and disease
    • Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
    • Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
    • Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
    • Identification of predictive markers for the generation of well-differentiated human induced pluripotent stem cell-derived kidney organoids
    • Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
    • Inferring and perturbing cell fate regulomes in human brain organoids
    • Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids
    • Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
    • Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping
    • Intersection of nanomaterials and organoids technology in biomedicine
    • Legal Notice
    • Liver organoids: a promising three-dimensional model for insights and innovations in tumor progression and precision medicine of liver cancer
    • Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week
    • Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth
    • Maturation and circuit integration of transplanted human cortical organoids
    • Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids
    • Mice hepatic organoids for modeling nonalcoholic fatty liver disease and drug response
    • Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
    • Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
    • Modeling neurodegeneration with mutant-tau organoids
    • Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
    • Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
    • Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
    • Multiplexed bulk and single-cell RNA-seq hybrid enables cost-efficient disease modeling with chimeric organoids
    • Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
    • News
    • One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
    • Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids
    • Organoid service platforms
    • Organoids and microphysiological systems: Promising models for accelerating AAV gene therapy studies
    • Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization
    • Organoids: new frontiers in tumor immune microenvironment research
    • Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease
    • Patient-derived xenografts and organoids model therapy response in prostate cancer
    • Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids
    • Platform access
    • Privacy
    • Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
    • RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
    • RESEARCH
    • RESOURCES
    • Retinoblastoma from human stem cell-derived retinal organoids
    • SARS-CoV-2 infection and replication in human gastric organoids
    • Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids
    • Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
    • Services
    • Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids
    • Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
    • Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
    • Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids
    • Spin glasses, error correcting codes, and synchronization of human stem cell organoids
    • Survival and functional integration of human embryonic stem cell-derived retinal organoids after shipping and transplantation into retinal degeneration rats
    • Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity
    • The drug-induced phenotypic landscape of colorectal cancer organoids
    • The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
    • Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids
    • Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
    • Training
    • Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
    • Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?
    • Welcome
    • WORKING GROUPS
    • Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation
    • Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids
    • γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

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    Archive

    • août 2024
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    • mars 2021
    • février 2021

    About this website

    The 3D-Hub-O website was created on an independent initiative, publications reflect only the views of the project owner.

    Contact

    Email : organoide.3d-hub-o@inserm.fr
    Centre de Recherche en Cancérologie de Marseille
    27 bd Lei Roure
    13273 Marseille cedex 09

    3D-HUB-O PLATFORM DIRECTION

    Scientific manager: Géraldine GUASCH
    Technical manager: Véronique CHEVRIER

    © Copyright 2024 - 3D-Hub Organoids
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