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A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids (Nature Communications, 2021)
General organoid newsIdentification of SARS-CoV-2 inhibitors using lung and colonic organoids (Nature, 2021)
General organoid newsRSS feeds on organoids
Pubmed
- KRAS degradation averts PDAC chemoresistance 28 mars 2024No abstractLaura Leonhardt
- Generating human bone marrow organoids for disease modeling and drug discovery 27 mars 2024The bone marrow supports and regulates hematopoiesis, responding to physiological requirements for blood cell production over ontogeny and during pathological challenges. Interactions between hematopoietic cells and niche components are challenging to study mechanistically in the human context, but are important to delineate in order to explore the pathobiology of blood and bone marrow disorders. Organoids […]Aude-Anais Olijnik
- Trophoblast organoid systems to study human placentation 26 mars 2024Human trophoblast organoids provide a valuable in vitro system to investigate human placental development and function. In this issue of Developmental Cell, Shannon et al. benchmark two organoid models against primary trophoblast at single-cell resolution, identifying their strengths and limitations.Qian Li
- Organoid-based personalized medicine: from tumor outcome prediction to autologous transplantation 25 mars 2024Inter-individual variation largely influences disease susceptibility, as well as response to therapy. In a clinical context, the optimal treatment of a disease should consider inter-individual variation and formulate tailored decisions at an individual level. In recent years, emerging organoid technologies promise to capture part of an individual's phenotypic variability and prove helpful in providing clinically […]Abel Soto-Gamez
- Past and Future of Alveolar Organoids for Lung Regenerative Medicine 25 mars 2024The lung is regarded as having limited regenerative capacity, and there are few treatment options for refractory lung diseases, such as interstitial pneumonia. Lung transplantation is the final option available in some scenarios. Research in this area has been slow owing to the complex structure of the lung for efficient gas exchange between the alveolar […]Ryuta Mikawa
- Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease 22 mars 2024Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe neurological disease, the highly prevalent PeV-A1 is not associated with CNS disease. Here, we expand our current understanding of these differences in PeV-A CNS disease using human brain organoids and […]Pamela E Capendale
- The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex 22 mars 2024Neocortex expansion during evolution is linked to higher numbers of neurons, which are thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells during development. Here, we show that EREG, encoding the growth factor EPIREGULIN, is expressed in the human developing neocortex and in gorilla cerebral organoids, but not in the […]Paula Cubillos
- Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism 21 mars 2024During epithelial tissue patterning, morphogens operate across multiple length scales to instruct cell identities. However, how cell fate changes are coordinated over these scales to establish spatial organization remains poorly understood. Here, we use human neural tube organoids as models of epithelial patterning and develop an in silico approach to define conditions permissive to patterning. […]Abdel Rahman Abdel Fattah
- BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response 20 mars 2024Modeling immuno-oncology by using patient-derived material and immune cell co-cultures can advance our understanding of immune cell tumor targeting in a patient-specific manner, offering leads to improve cellular immunotherapy. However, fully exploiting these living cultures requires analysis of the dynamic cellular features modeled, for which protocols are currently limited. Here, we describe the application of […]Maria Alieva
- SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis 20 mars 2024The intestine is a highly metabolic tissue, but the metabolic programs that influence intestinal crypt proliferation, differentiation, and regeneration are still emerging. Here, we investigate how mitochondrial sirtuin 4 (SIRT4) affects intestinal homeostasis. Intestinal SIRT4 loss promotes cell proliferation in the intestine following ionizing radiation (IR). SIRT4 functions as a tumor suppressor in a mouse […]Sarah A Tucker
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