Organoids focus

The OT news section is dedicated to the latest research about and featuring organoids.

Selected News

RSS feeds on organoids

RSS Pubmed

  • HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease 15 juin 2021
    Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the transcription factors that regulate their expression. We demonstrated increased expression of […]
    Jing Zhang
  • Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics 15 juin 2021
    Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial […]
    Nagarjuna R Cheemarla
  • Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum 9 juin 2021
    Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors with an intrinsic capacity to generate both lineages exist and how such a fate decision […]
    Tingting Zhang
  • Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo 8 juin 2021
    In the liver, the bile canaliculi of hepatocytes are connected to intrahepatic bile ducts lined with cholangiocytes, which remove cytotoxic bile from the liver tissue. Although liver organoids have been reported, it is not clear whether the functional connection between hepatocytes and cholangiocytes is recapitulated in those organoids. Here, we report the generation of a […]
    Naoki Tanimizu
  • Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases 4 juin 2021
    No abstract
    Jonas Simon Fleck
  • Mapping human brain organoids on a spatial atlas 4 juin 2021
    Brain organoids are tridimensional, self-organizing cultures derived from pluripotent stem cells that recapitulate aspects of human neurodevelopment and can be applied toward investigating neural disease and evolution. In this issue of Cell Stem Cell, Fleck et al. (2021) describe a computational platform for mapping cell identity in organoids.
    Yuki Miura
  • Pancreatic plasticity: Unlocking exocrine lineage specification 4 juin 2021
    In this issue of Cell Stem Cell, Huang et al. (2021) and Breunig et al. (2021) developed human stem-cell-derived organoid culture systems to recapitulate pancreatic acinar and ductal lineages. This provides opportunities to study cellular plasticity and transformation in pancreatic cancer initiation and progression.
    Jason R Pitarresi
  • NOTUM from Apc-mutant cells biases clonal competition to initiate cancer 3 juin 2021
    The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling¹, but reduced secretion of WNT ligands increases the ability of Apc-mutant intestinal stem cells to colonize a crypt (known as fixation)². Here we investigated […]
    Dustin J Flanagan
  • The next generation of endothelial differentiation: Tissue-specific ECs 3 juin 2021
    Endothelial cells (ECs) sense and respond to fluid flow and regulate immune cell trafficking in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous tissue-specific characteristics. Human pluripotent stem cells (hPSCs) can potentially be harnessed to capture this heterogeneity and further elucidate endothelium behavior to satisfy the need for increased accuracy and breadth […]
    Jane Nguyen
  • Actuation enhances patterning in human neural tube organoids 28 mai 2021
    Tissues achieve their complex spatial organization through an interplay between gene regulatory networks, cell-cell communication, and physical interactions mediated by mechanical forces. Current strategies to generate in-vitro tissues have largely failed to implement such active, dynamically coordinated mechanical manipulations, relying instead on extracellular matrices which respond to, rather than impose mechanical forces. Here, we develop […]
    Abdel Rahman Abdel Fattah