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    A think tank dedicated to organoid research

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Organoid research

Organoids at all scales

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Patient-derived organoid models

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Selected news

Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver (Nature Protocols, 2021)

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About OT

Organoids tank (OT) is intended to federate a scientific community on organoids latest innovation and discoveries, to promote technological offer by existing organoid platforms, to foster new partnerships between fundamental and clinical researchers and to accelerate our understanding of human biology and provide unprecedented opportunities to improve human health (…)

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501.2 Million $

Organoids and Spheroids Market value in 2020

2.1 billion $

Revenue forecast in 2027

1728 Publications

on organoids in 2020

1906 Harrison

Hanging drop cell culture method

NEW MODELS TO STUDY TISSUE HOMEOSTASIS AND TUMORIGENESIS

Understanding of mammalian biology at the tissue level and studying organ development and how they change during disease state in humans has been difficult due to ethical concerns and inaccessibility of sample. Conventional monolayer cell cultures, derived from human tissue have been used for decades to create experimental tools to study basic and cancer biology.

Organoid service platforms

FOCUS

Center for Stem Cell & Organoid Medicine (CuSTOM) – Human ips

This confocal microscopic image shows a tiny bioengineered human liver organoid grown in the lab with pluripotent stem cells. The mini-organ is accumulating inflammation and fat lipids (bluish bubble-like shapes), which are hallmarks of fatty liver and Wolman disease. The ability to closely mimic naturally occurring human liver disease in a research laboratory allowed researchers in the U.S. and Japan to determine underlying disease biology and search for much-needed new treatments, they report in Cell Metabolism.

Photo credits Cincinnati Children’s

CuSTOM platform